PUBLICATIONS (Peer reviewed)  

31. Das, S.K., Rehman, I., Ghosh, A., Sengupta, S., Majumder, P., Jana, B and Das BB*. Poly(ADP-ribose) polymers regulate DNA topoisomerase I (Top1) nuclear dynamics and camptothecin sensitivity in living cells. Nucleic. Acids Res., 2016 (In Press).

30. Majumdar P, Bathula C, Basu SM, Das SK, Agarwal R, Hati S, Singh A, Sen S, Das BB*. Design, synthesis and evaluation of thiohydantoin derivatives as potent topoisomerase I (Top1) inhibitors with anticancer activity. 2015; Eur J Med Chem. 102:540-51.

29. Pommier Y, Huang SY, Gao R, Das BB, Murai J, Marchand C. Tyrosyl-DNA-phosphodiesterases (TDP1 and TDP2). DNA Repair (Amst). 2014 Jul; 19:114-29. (Review)

28. Das BB*, Huang S.N., Murai J., Rehman I., Amé J.-C., Sengupta S., Das S.K., Majumdar P., Zhang H., Biard D., Majumder H.K., Schreiber V., Pommier Y.*, PARP1-TDP1 coupling for the repair of topoisomerase I-induced DNA damage, Nucleic. Acids Res., 2014 Apr;42(7):4435-49. * Corresponding authors.

27. Rui G*., Das BB*., Chatterjee R., Vinson C and Pommier Y., Epigenetic and genetic inactivation of tyrosyl-DNA-phosphodiesterase 1 (TDP1) in human lung cancer cells. DNA Repair, 2014 Jan; 13:1-9. doi: 10.1016/j.dnarep.2013.09.001. Epub 2013 Dec 16. * Joint first author. 

26. Murai J., Huang SY., Das BB, Renaud A., Zhang Y., Doroshow JH., Ji J.,Takeda S and Pommier Y.  Trapping of PARP1 and PARP2 by Clinical PARP Inhibitors. Cancer Research 72(21): 5588-99. (2012)

25. Murai J., Huang SY., Das BB, Dexheimer TS., Takeda S and Pommier Y. Tyrosyl-DNA     phosphodiesterase 1 (TDP1) repairs DNA damages induced by topoisomerases I and II, and base alkylation in vertebrate cells. J. Biol. Chem, 287(16):12848-57. (2012) 

24. Douarre C., Sourbier C., Dalla Rosa I., Das BB., Redon CE., Zhang H., Neckers L and Pommier Y. Mitochondrial Topoisomerase I is Critical for Mitochondrial Integrity and Cellular Energy Metabolism. PLoS One.;7(7):e41094. (2012) 

23. Das, BB, Dexheimer TS, Maddali K and Pommier Y. Role of Tyrosyl DNA Phosphodiesterase (TDP1) in mitochondria. Proc Natl Acad Sci U S A. 16;107(46):19790-19795. 2010.

22. Das, BB, Antony S, Gupta, S, Dexheimer TS, Redon CE, Garfield S, Shiloh Y and Pommier Y. Optimal function of the DNA repair enzyme TDP1 requires its phosphorylation by ATM and/or DNA-PK. EMBO J. 28, 3667-3680. 2009.

21. Sordet, O., Redon, C, Guirouilh-Barbat J., Smith S, Solier, S, Douarre, C, Conti, C, Nakamura, A, Das, BB, Nicolas E, Kohn, KW, Bonner, WM, Pommier, Y. Ataxia telangiectasia mutated activation by transcription- and topoisomerase I-induced DNA double-strand breaks. EMBO Rep . 10(8):887-93. 2009.

20. Das BB, Ganguly A, Majumder HK. DNA topoisomerases of Leishmania: the potential targets for anti-leishmanial therapy. Adv Exp Med Biol.; 625:103-15. Review. 2008.

19. Roy A, Ganguly A, BoseDasgupta S, Das BB, Pal C, Jaisankar P, Majumder HK. Mitochondria-dependent reactive oxygen species-mediated programmed cell death induced by 3,3'-diindolylmethane through inhibition of F0F1-ATP synthase in unicellular protozoan parasite Leishmania donovani. Mol Pharmacol. , 74, 1292-307. 2008.

18. BoseDasgupta S, Das BB, Sengupta S, Ganguly A, Roy A, Dey S, Tripathi G, Dinda B, Majumder HK. The caspase-independent algorithm of programmed cell death in Leishmania induced by baicalein: the role of LdEndoG, LdFEN-1 and LdTatD as a DNA 'degradesome'. Cell Death Differ, 10, 1629-40. 2008.

17. Bosedasgupta S., Das BB. Ganguly A., Roy A., Majumder HK. Amino acids 39-456 of the large subunit and 210-262 of the small subunit constitute the minimal functionally interacting fragments of the unusual heterodimeric topoisomerase IB of Leishmania. Biochem J. 15; 481-9. 2008.

16. Bosedasgupta S., Ganguly A., Das BB., Roy A., Majumder HK. The large subunit of Leishmania topoisomerase I functions as the 'molecular steer' in type IB topoisomerase. Molecular Microbiology. 67, 31-46. 2008.

15. Roy A., Das BB., Ganguly A., Bosedasgupta S., Khalko NV., Pal C., Dey S., Giri VS. and Majumder HK An insight into the mechanism of inhibition of unusual bi-subunit topoisomerase I from Leishmania donovani by 3,3'-di-indolylmethane, a novel DNA topoisomerase I poison with a strong binding affinity to the enzyme.    Biochem J. 409, 611-22. 2008.

14. Ganguly A., Das BB., Roy A., Sen N., Dasgupta SB., Mukhopadyay S., Majumder HK., Betulinic acid, a catalytic inhibitor of topoisomerase I, inhibits reactive oxygen species-mediated apoptotic topoisomerase I-DNA cleavable complex formation in prostate cancer cells but does not affect the process of cell death. Cancer Res. 24: 11848-58. 2007.

13. Das BB., Bosedasgupta S., Ganguly A., Majumder S., Roy A and Majumder HK Leishmania donovani bisubunit topoisomerase I gene fusion leads to an active enzyme with conserved type IB enzyme function. FEBS J. 274:150-63. 2007.

12. Sen N., Banerjee B., Das BB., Ganguly A., Sen T., Pramanik S., Mukhopadhay S and Majumder HK Apoptosis is induced in leishmanial cells by a novel protein kinase inhibitor withaferin A and is facilitated by apoptotic topoisomerase I-DNA complex. Cell Death Differ. 2. 358-67. 2007.

11. Das BB., Sengupta T., Ganguly A. and Majumder HK., Topoisomerases of kinetoplastid parasites: why so fascinating? Molecular Microbiology. 62, 917-27. 2006.

10. Sen N, Banerjee B, Gupta SS, Das BB, Ganguly A, Majumder HK. Leishmania donovani: dyskinetoplastid cells survive and proliferate in the presence of pyruvate and uridine but do not undergo apoptosis after treatment with camptothecin. Exp Parasitol. 115. 215-9. 2007.

9. Ganguly A., Das BB., Sen N., Roy A., Dasgupta SB and Majumder HK. LeishMan'  topoisomerase I: an ideal chimera for unraveling the role of the small subunit of unusual bi-subunit topoisomerase I from Leishmania donovani. Nucleic Acids Res. 34, 6286-97. 2006.

8. Das BB, Sen N, Dasgupta SB, Ganguly A, Majumder HK. Differential induction of Leishmania donovani bi-subunit topoisomerase I-DNA cleavage complex by selected flavones and camptothecin: activity of flavones against camptothecin-resistant topoisomerase I. Nucleic Acids Res. 34, 1121-32. 2006.

7. Sen N, Das BB, Ganguly A, Banerjee B, Sen T and  Majumder HK. Leishmania donovani: intracellular ATP level regulates apoptosis-like death in luteolin induced dyskinetoplastid cells. Exp Parasitol. 114(3):204-14. 2006.

6. Das BB, Ganguly A, Majumder HK. Topoisomerase research of kinetoplasti parasite Leishmania, with special reference to development of therapeutics. Indian J Med Res. 123(3):221-32. Review. 2006.

5. Gosh S, Bandyopadhyay S, Pal S, Das BB, Bhattacharya DK, Mandal C.   Increased interferon gamma production by peripheral blood mononuclear cells in response to stimulation of overexpressed disease-specific 9-O-acetylated sialoglycoconjugates in children suffering from acute lymphoblastic leukaemia. Br J Haematol. 128, 35-41. 2005.

4. Das BB ., Sen N, Dasgupta SB, Ganguly A, Majumder HK. N-terminal region of the large subunit of Leishmania donovani bi-subunit topoisomerase I is involved in DNA relaxation and interaction with smaller subunit. J Biol Chem. 280, 16335-44. 2005.

3. Sen N, Das BB, Ganguly A, Mukherjee T, Bandyopadhyay S, Majumder HK. Camptothecin-induced imbalance in intracellular cation homeostasis regulates programmed cell death in unicellular hemoflagellate Leishmania donovani. J Biol Chem. 279, 52366-75. 2004.

2. Sen N, Das BB, Ganguly A, Mukherjee T, Tripathi G, Bandyopadhyay S, Rakshit S, Sen T, Majumder HK. Camptothecin induced mitochondrial dysfunction leading to programmed cell death in unicellular hemoflagellate Leishmania donovani. Cell Death Differ. 8, 924-36. 2004.

1. Das BB., Sen N, Ganguly A, Majumder HK. Reconstitution and functional characterization of the unusual bi-subunit type I DNA topoisomerase from Leishmania donovani. FEBS Lett. 565, 81-8. 2004.



  1. Dexhimer TS., Huang Shar-yin, Das BB and Pommier Y. Tyrosyl-DNA phosphodiesterase 1. 2011, Book: DNA Topoisomerases and Cancer: Publisher: Springer, NY USA (in press).
  2. Das BB, Ganguly A, Majumder HK. DNA topoisomerases of Leishmania: the potential targets for anti-leishmanial therapy. Book: Drug Targets in Kinetoplastid Parasites; Publisher: Springer, NY USA. 2008.


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